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The fatigue: is severe does not improve with rest is not due to activity was not previously present For a diagnosis of ME/CFS, this fatigue and the resulting decrease in activity levels must last Post-exertional malaise A person with post-exertional malaise (PEM) will experience a crash after physical or mental exertion

Cost: Approximately $150-$300 monthly ($1800-$3600 yearly) for peptides plus $200-$500 yearly for exams and AREDS2 supplements

Figure 3 3.3 Socioeconomic and health system impact PD imposes a significant socioeconomic burden, including direct healthcare costs (e.g., medications, hospitalizations, and surgery) and indirect costs (e.g., lost income, caregiver absenteeism, and reduced productivity)

Sanchez-Rodriguez et al., 2020