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The quinone metabolites of ISO that form superoxide anions and other reactive oxygen species (ROS) when they react with oxygen might cause oxidative stress by interfering with antioxidant enzymes [124]

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Although SNP and NPH had the same dosage of OA-NPs, there was still a certain gap between the therapeutic effect of SNP and NPH in vivo, because NPH delivered more OA to the lesional site, thus playing a greater pharmacological role

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