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AOD-9604 is a lab-tested synthetic 16-amino-acid C-terminal fragment

It also prevented from the depletion of antioxidant enzymes glutathione peroxidase, glutathione reductase, glutathione-S-transferase, catalase, and superoxide dismutase (SOD) and alteration of the morphology of the hippocampal pyramidal neurons compared to the STZ-induced group [81]

In addition, exercise can induce autophagy in mitochondria through the AMPK-ULK1 pathway to delay symptom progression (Figure 2) [135]

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