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N-3 PUFAs also inhibit excessive proliferation of GCs in ovarian follicles, by which n-3 PUFAs weaken PCOS, and identifying yes-associated protein 1 (Nrf2) as a potential therapeutic target for regulating GCs in PCOS (171)

Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11

Variations in the GLP1R gene (such as rs6923761) determine how sensitive your gut receptors are to the medication, while GIPR variants affect your body's broader appetite-control response

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An overview of the spectrum of adverse effects is in Box 14.1