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Sertraline HCl (generic Zoloft) is one of only two SSRIs with FDA approval specifically for PMDD, and research shows its effective across all major symptom clusters for this mental health condition: Depression Anger Food cravings Concentration issues Physical discomfort Other SSRIs are also effective for PMDD

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Nevertheless, the ubiquitous GSH-GSSG redox system is the most widely studied one 6,7