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Obesity: Prevalence, causes, consequences, management, preventive strategies and future research directions

Specifically, they increase satiety and slow gastric emptying, leading to reduced caloric intake and clinically meaningful weight lossapproximately 15 percent in clinical trials.[13] Crucially, by targeting the underlying drivers of obesity such as insulin resistance and hormonal dysregulation, GLP-1s represent a potential paradigm shift in obesity treatment

However, after 40 to 42 weeks, no significant difference in estimated glomerular filtration rate was observed

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