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Combining it with bupropion does raise a CYP2D6 problem: bupropion roughly doubles vortioxetine exposure, so the dose has to be managed

References Jimnez-Reina, L., Caete, R., de la Torre, M

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As with bariatric surgery or any other medical intervention, long-term success comes from addressing the whole person : a balanced diet, personalized exercise plan, consistent sleep (78 hours per night), stress management, and mental well-being

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