i am not losing weight on semaglutide Why Semaglutide? Not losing weight on semaglutide?

References: Xie et al

In SURPASS-2, which compared tirzepatide to semaglutide 1 mg in 1,879 patients with type 2 diabetes, tirzepatide 5 mg, 10 mg, and 15 mg reduced systolic blood pressure from baseline by 5.6, 7.4, and 8.0 mmHg respectively at 40 weeks, compared to 5.3 mmHg with semaglutide

activation of glucagon receptors causes a variety of effects

Genetic variations What complicates things a little more is that some people have a genetic variation (methylenetetrahydrofolate ( MTHFR) C677T SNP) which inhibits the way the body processes folic acid and other important B vitamins

These latter AEs were more common in the anti-ActA and combination groups, and while these are difficult to assess in rodents and primates, we did not observe any of these in any of our preclinical in vivo studies