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HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer

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For example, mitophagy mediated MQC heavily depends on efficient lysosome degradation, whose dysregulation reversely suppresses mitochondrial function, so they all interplay by each other to form a vicious cycle, participating in the pathogenesis of neurodegenerative diseases

Immune activation Even after antimicrobial treatment, inflammatory and immune patterns may continue to drive symptoms